Oncology

Overview

The Oncology research area is composed by nine groups addressing the principal unsolved issues in cancer. Their research covers fields such as child and adolescent cancer, melanoma, Gynecology, Urology, cancer stem cells and the molecular mechanisms of the tumor pathologies.

There are also three groups from the CIBBIM-Nanomedicine. These groups study the use of nanotechnology in biomedical applications to improve therapeutic strategies and diagnostics.

Publications

125

total

725.353

impact factor

5.803

average impact factor

Group Leader: Santiago Ramon y Cajal Agüeras

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Combing pathology and molecular biology, the aim of our group is to unravel the molecular mechanisms in cancer progression and chemotherapeutic drug resistance. In this line, we continued our work on cellular stress resistance in collaboration with the group of Nahum Sonneberg (McGil University, Canada). This work was published in Oncogene (Ramon Y Cajal S, et al) and PNAS (Robichaud N, et al). Through our expertise in pathology, we could furthermore contribute to groundbreaking research in cancer (e.g. Priego N et al, Nat Med) and obtained support as members of the LaCaixa research grant 2018 (PI: Fatima Gebauer, CRG). While maintaining our focus on tumor biology, we are currently moving towards the field of tumor heterogeneity, and published our first results in 2018 (Carrió M et al, Hum Mutat). In the coming years, we aim at studying the mechanisms underlying cellular communication through secreted factors (exosomes) and gap junctions (Trond Aasen) within a heterogeneous tumor.

39

total

310^.348

impact factor

7^.958

average impact factor

SELECTED ARTICLES

Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N.
Beyond molecular tumor heterogeneity: protein synthesis takes control.
Oncogene. 2018 May;37(19):2490-2501.
doi: 10.1038/s41388-018-0152-0
IF: 6.854
Carrió M, Gel B, Terribas E, Zucchiatti AC, Moliné T, Rosas I, Teulé Á, Ramón Y Cajal S, López-Gutiérrez JC, Blanco I, Castellanos E, Lázaro C,Stemmer-Rachamimov A, Romagosa C, Serra E.
Analysis of intratumor heterogeneity in Neurofibromatosis type 1 plexiform neurofibromas and neurofibromas with atypical features: Correlating histological and genomic findings.
Hum Mutat. 2018 May 17.
doi: 10.1002/humu.23552.
IF: 5.359
Priego N, Zhu L, Monteiro C, Mulders M, Wasilewski D, Bindeman W, Doglio L, Martínez L, Martínez-Saez E, Cajal SRY, Megías D, Hernández-Encinas E, Blanco-Aparicio C, Martínez L, Zarzuela E, Muñoz J, Fustero-Torres C, Pineiro E, Hernández-Laín A, Bertero L, Poli V, Sánchez-Martínez M, Menendez JA, Soffietti R, Bosch-Barrera J, Valiente M.
STAT3 labels a subpopulation of reactive astrocytes required for brain metastasis.
Nat Med. 2018 Jun 11
doi: 10.1038/s41591-018-0044-4
IF: 32.621
Robichaud N, Hsu BE, Istomine R, Alvarez F, Blagih J, Ma EH, Morales SV, Dai DL, Li G, Souleimanova M, Guo Q, Del Rincon SV, Miller WH Jr, Ramón Y Cajal S, Park M, Jones RG, Piccirillo CA, Siegel PM, Sonenberg N.
Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils.
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):E2202-E2209.
doi: 10.1073/pnas.1717439115.
IF: 9.504
Méndez O, Peg V, Salvans C, Pujals M, Fernández Y, Abasolo I, Pérez J, Matres A, Valeri M, Gregori J, Villarreal L, Schwartz S Jr, Ramon Y Cajal S, Tabernero J, Cortés J, Arribas J, Villanueva J.
Extracellular HMGA1 Promotes Tumor Invasion and Metastasis in Triple-Negative Breast Cancer.
Clin Cancer Res. 2018 Dec 15;24(24):6367-6382.
doi: 10.1158/1078-0432.
IF: 10.199

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Oncology

Overview

Publications

Group Leader: Santiago Ramon y Cajal Agüeras

Research Areas