Vascular Biology and Metabolism (VAM)

Overview

The Vascular Biology and Metabolism (VAM) area was created to enable a comprehensive, cooperative and multidisciplinary approach to research, development and transference of solutions for a group of diseases that are the leading cause of morbidity and mortality in the world: cardio- and neurovascular diseases, diabetes-metabolic syndrome and kidney failure.

This area also includes a group focused on Ophtalmology research and the Medical Molecular Imaging multidisciplinary group.

Publications

209

total

1181.950

impact factor

5.655

average impact factor

Group Leader: Anna Rosell Novel

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We have started the MAGBBRIS European project, coordinated by our group, which will generate new biomaterials to encapsulate the secretoma of endothelial progenitor cells with therapeutic properties for neurorepair in the context of the stroke. In preclinical models we have characterized the proteome of rat cerebrospinal fluid in cerebral ischemia by identifying interesting targets. At the MEGASTROKE Consortium, we identified 32 loci associated with stroke in more than half a million individuals. We have also initiated projects for the discovery of biomarkers of the stroke-associated infection leading a multicenter study, the Multi-Bio-Targets project for the study of prognostic biomarkers as new therapeutic targets for stroke and two new stroke-funded projects La Marató. In prevention, we have described the association of arterial stiffness with different markers of small vein disease and we have begun its evaluation in a new project in post-stroke cognitive impairment.

35

total

226^.270

impact factor

6^.460

average impact factor

SELECTED ARTICLES

Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data.
Al-Shahi Salman R, Frantzias J, Lee RJ, Lyden PD, Battey TWK, Ayres AM, Goldstein JN, Mayer SA, Steiner T, Wang X, Arima H, Hasegawa H, Oishi M, Godoy DA, Masotti L, Dowlatshahi D, Rodriguez-Luna D, Molina CA, Jang DK, Davalos A, Castillo J, Yao X, Claassen J, Volbers B, Kazui S, Okada Y, Fujimoto S, Toyoda K, Li Q, Khoury J, Delgado P, Sabin JA, Hernandez-Guillamon, et al.
Lancet Neurology. 2018 Oct;17(10):885-894.
DOI: 10.1016/S1474-4422(18)30253-9
IF: 27.14
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes.
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese AK, van der Laan SW, Gretarsdottir S, Anderson CD, Chong M, Adams HHH, Ago T, Almgren P, Amouyel P, Ay H, Bartz TM, Benavente OR, Bevan S, Boncoraglio GB, Brown RD Jr, Butterworth AS, Carrera C, et al.
Nature Genetics. 2018 Apr;50(4):524-537.
DOI: 10.1038/s41588-018-0058-3.
IF: 27.13
PATJ Low Frequency Variants Are Associated with Worse Ischemic Stroke Functional Outcome: A Genome-Wide Meta-Analysis.
Mola-Caminal M, Carrera C, Soriano-Tarraga C, Giralt Steinhauer E, Diaz-Navarro RM, Tur S, Jimenez C, Medina-Dols A, Cullell N, Torres-Aguila NP, Muino E, Rodri Guez-Campello , Ois A, Cuadrado-Godia E, Vivanco-Hidalgo RM, Hernandez-Guillamon , Sole M, Delgado P, Bustamante A, Garcia-Berrocoso T, et al.
Circulation Research. 2019 Jan 4;124(1):114-120.
DOI: 10.1161/CIRCRESAHA.118.313533.
IF: 15.21
Usefulness of ADAMTS13 to predict response to recanalization therapies in acute ischemic stroke. Bustamante A, Ning M, Garcia-Berrocoso T, Penalba A, Boada C, Simats A, Pagola J, Ribo M, Molina C, Lo E, Montaner J.
Neurology. 2018 Mar 20;90(12):e995-e1004.
DOI: 10.1212/WNL.0000000000005162.
IF: 7.61
Prevalence of hippocampal enlarged perivascular spaces in a sample of patients with hypertension and their relation with vascular risk factors and cognitive function. Jimenez-Balado J, Riba-Llena I, Garde E, Valor M, Gutierrez B, Pujadas F, Delgado P.
Journal of Neurology and Neurosurgery and Psychiatry. 2018 Jun;89(6):651-656.
DOI: 10.1136/jnnp-2017-316724.
IF: 7.14

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Vascular Biology and Metabolism (VAM)

Overview

Publications

Group Leader: Anna Rosell Novel

Research Areas