Neurosciences

Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. Thirteen groups are currently part of this area, working closely with top clinicians at the hospital. The area encompasses different aspects related to neuroscience, such as neural development, neurodegeneration, neuroimmunology, neurological pain, mental health, neurosurgery, pediatric neurology or neuroimaging

There are groups also focused on cell signaling and apoptosis and translational bioinformatics.

Publications

242

total

1850.832

impact factor

7.648

average impact factor

Group Leader: Joan Sahuquillo Barris

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In 2018 we worked in brain contusions (BCs), one of the most frequent lesions in patients with traumatic brain injury. BCs increase their volume due to peri-lesional edema formation and/or hemorrhagic transformation. This may have deleterious consequences and its mechanisms are still poorly understood. We previously identified de novo upregulation sulfonylurea receptor (SUR1) in human BCs. This year, we studied the expression of the pore-forming subunit of KATP (Kir6.2) and identify its localization in different cell types, suggesting that further research on SUR1-regulated ionic channels may lead to a better understanding of key pathogenic mechanisms and identify novel targeted therapeutic strategies. During 2018, we organized an international symposium on neurocritical patients (PIC 2018) with 450 participants. Additionally, we remained involved in the ERN CRANIO, with a new COST Action project, and in 5 national and European grants (FIS, KidsBrainIT, BitMap, Marató TV3 and AECC)

23

total

135^.334

impact factor

5^.884

average impact factor

SELECTED ARTICLES

Martinez-Ricarte F, Mayor R, Martinez-Saez E, Rubio-Perez C, Pineda E, Cordero E, Cicuendez M, Poca MA, Lopez-Bigas N, Ramon Y Cajal S, Vieito M, Carles J, Tabernero J, Vivancos A, Gallego S, Graus F, Sahuquillo J, Seoane J.
Molecular diagnosis of diffuse gliomas through sequencing of cell-free circulating tumour DNA from cerebrospinal fluid.
Clinical Cancer Research. 2018 Jun 15;24(12):2812-2819. Epub 2018 Apr 3.
DOI: 10.1158/1078-0432.CCR-17-3800.
FI: 10,199
Urbizu A, Martin BA, Moncho D, Rovira A, Poca MA, Sahuquillo J, Macaya A, Español MI.
Machine learning applied to neuroimaging for diagnosis of adult classic Chiari malformation: role of the basion as a key morphometric indicator.
Journal of neurosurgery. 2018 Sep;129(3):779-791. Epub 2017 Oct 20.
DOI: 10.3171/2017.3.JNS162479.
FI: 4,319
Gerzanich V, Stokum JA, Ivanova S, Woo SK, Tsymbalyuk O, Sharma A, Akkentli F, Imran Z, Aarabi B, Sahuquillo J, Simard JM.
Sulfonylurea Receptor 1, Transient Receptor Potential Cation Channel Subfamily M Member 4, and KIR6.2:Role in Hemorrhagic Progression of Contusion.
Journal of Neurotrauma. 2018 Oct 4.
DOI: 10.1089/neu.2018.5986.
FI: 5.00
Castro L, Noelia M, Vidal-Jorge M, Sanchez-Ortiz D, Gandara D, Martinez-Saez E, Cicuendez M, Poca MA, Simard JM, Sahuquillo J.
Kir6.2, the pore-forming subunit of ATP-sensitive K+ channels, is overexpressed in human post-traumatic brain contusions
Journal of Neurotrauma. 2018 Jul 24.
DOI: 10.1089/neu.2017.5619.
FI: 5.00
Devereaux PJ, Duceppe E, Guyatt G, Tandon V, Rodseth R, Biccard BM, Xavier D, Szczeklik W, Meyhoff CS, Vincent J, Franzosi MG, Srinathan SK, Erb J, Magloire P, Neary J4, Rao M, Rahate PV, Chaudhry NK, Mayosi, de Nadal M, Iglesias PP, Berwanger O, Villar JC, Botto F, Eikelboom JW, Sessler DI, Kearon C, Pettit S, Sharma M, Connolly SJ, Bangdiwala SI, Rao-Melacini P, Hoeft A, Yusuf S; MANAGE Investigators.
Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial.
Lancet. 2018 Jun 9;391(10137):2325-2334.
DOI: 10.1016/S0140-6736(18)30832-8
FI: 52,253

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Neurosciences

Overview

Publications

Group Leader: Joan Sahuquillo Barris

Research Areas