Vascular Biology and Metabolism (VAM)

Overview

The Vascular Biology and Metabolism (VAM) area was created to enable a comprehensive, cooperative and multidisciplinary approach to research, development and transference of solutions for a group of diseases that are the leading cause of morbidity and mortality in the world: cardio- and neurovascular diseases, diabetes-metabolic syndrome and kidney failure.

This area also includes a group focused on Ophtalmology research and the Medical Molecular Imaging multidisciplinary group.

Publications

209

total

1181.950

impact factor

5.655

average impact factor

Group Leader: Rafael Simó

team

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We finished the EUROCONDOR project funded by the EC (FP7-HEATH-278040-2. 6M€). This project, coordinated by Prof. Simó, includes a clinical trial that demonstrated for the first time that topical administration of neuroprotective drugs prevent the progression of retinal neurodegeneration in type 2 diabetic patients. In addition, the study showed that a significant proportion of patients with type 2 diabetes presented early microvascular disease without detectable neurodysfunction. This new comprehensive understanding of DR emphasizes the need for better phenotyping and stratification of patients with DR not only by using methods addressed to measure microvascular impairment, but also by incorporating measurements of retinal function.

We demonstrated that the assessment of retinal sensitivity in combination with parameters of fixation by using microperimetry could be a reliable method for detecting prodromal stages of dementia in the T2D population.

We have identified several SNPs for predicting the rate of sustained weight loss and diabetes remission after bariatric surgery.

17

total

84^.486

impact factor

4^.970

average impact factor

SELECTED ARTICLES

Sundstrom JM, Hernández C, Weber SR, Zhao Y, Dunklebarger M, Tiberti N, Laremore T, Simó-Servat O, Garcia-Ramirez M, Barber AJ, Gardner TW, Simó R.
Proteomic Analysis of Early Diabetic Retinopathy Reveals Mediators of Neurodegenerative Brain Diseases.
Invest Ophthalmol Vis Sci. 2018 May 1;59(6):2264-2274.
doi: 10.1167/iovs.17-23678.
IF: 3,388 (Q1)
Simó R, Stitt AW, Gardner TW.
Neurodegeneration in diabetic retinopathy: does it really matter?
Diabetologia. 2018 Sep;61(9):1902-1912.
DOI: 10.1007/s00125-018-4692-1
IF: 6,023 (Q1)
Sánchez D, Castilla-Marti M, Rodríguez-Gómez O, Valero S, Piferrer A, Martínez G, Martínez J, Serra J, Moreno-Grau S, Hernández-Olasagarre B, De Rojas I, Hernández I, Abdelnour C, Rosende-Roca M, Vargas L, Mauleón A, Santos-Santos MA, Alegret M, Ortega G, Espinosa A, Pérez-Cordón A, Sanabria Á, Ciudin A, Simó R, Hernández C, Villaoslada P, Ruiz A, Tàrraga L, Boada M.
Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer’s disease.
Sci Rep. 2018 Nov 5;8(1):16345.
doi: 10.1038/s41598-018-34577-3.
IF: 4,122 (Q1)
Palomino-Schätzlein M, Simó R, Hernández C, Ciudin A, Mateos-Gregorio P, Hernández-Mijares A, Pineda-Lucena A, Herance JR.
Metabolic fingerprint of insulin resistance in human polymorphonuclear leucocytes.
PLoS One. 2018 Jul 13;13(7):e0199351.
doi: 10.1371/journal.pone.0199351.
IF: 2,766 (Q1)
Capdevila J, Mayor R, Mancuso FM, Iglesias C, Caratù G, Matos I, Zafón C, Hernando J, Petit A, Nuciforo P, Cameselle-Teijeiro JM, Álvarez V, Recio JA, Tabernero J, Matias-Guiu X, Vivancos A, Seoane J.
Early evolutionary divergence between papillary and anaplastic thyroid cancers.
Ann Oncol. 2018 Jun 1;29(6):1454-1460.
DOI: 10.1093/annonc/mdy123
IF: 13,93 (D1)

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Vascular Biology and Metabolism (VAM)

Overview

Publications

Group Leader: Rafael Simó

Research Areas