Vascular Biology and Metabolism (VAM)

Overview

The Vascular Biology and Metabolism (VAM) area was created to enable a comprehensive, cooperative and multidisciplinary approach to research, development and transference of solutions for a group of diseases that are the leading cause of morbidity and mortality in the world: cardio- and neurovascular diseases, diabetes-metabolic syndrome and kidney failure.

This area also includes a group focused on Ophtalmology research and the Medical Molecular Imaging multidisciplinary group.

Publications

209

total

1181.950

impact factor

5.655

average impact factor

Group Leader: Anna Meseguer Navarro

team

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We focused on the study of renal tubular epithelium pathologies and the role of sex on disease expression, including: 1) inherited rare tubulopathies Dent 1 Disease (DD1) and Familial Hypomagnesemia with Hypercalciuria and Nephrocalcinosis (FHHNC); 2) mechanisms of tubular regeneration after injury to prevent kidney fibrosis and 3) role of HAVRC1/KIM-1 in clear cell renal cell carcinoma and kidney regenerative processes after injury. Seven Ph.D. thesis, one from the PhD4MD Program, are currently supervised by our group. We have strengthened research projects in collaboration with Patients Associations (ASDENT and HIPOFAM) and joined the Rare Kidney Stone Consortium (RKSC), led by the Mayo Clinic (MN, USA). We have stablished a collaboration with ASDENT and Nostrum Biodiscovery to generate a first-in-class candidate for Dent 1 disease, using the Mare Nostrum Supercomputing Center. Dr. Gema Ariceta coordinates the only Spanish member center at the European Rare Renal Diseases Network (ERKNet).

19

total

89^.349

impact factor

4^.703

average impact factor

SELECTED ARTICLES

Vall-Palomar M., Arévalo J., Ariceta G, Meseguer A.
Establishment of urinary exosome-like vesicles isolation protocol for FHHNC patients and evaluation of different exosomal RNA extraction methods.
Journal of Translational Medicine. 2018;16:278.1-9.
doi:10.1186/s12967-018-1651-z.
I .F.:3,24
Segarra A, Romero K, Agraz I, Ramos N, Madrid A, Carnicer C, Jatem E, Vilalta R, Lara LE, Ostos E, Valtierra N, Jaramillo J, Arredondo KV, Ariceta G, Martinez C.
Mesangial C4d Deposits in Early IgA Nephropathy.
Clin J Am Soc Nephrol. 2018 Feb 7;13(2):258-264.
doi: 10.2215/CJN.02530317.
I.F. 6,243
Schaefer F, Ardissino G, Ariceta G, Fakhouri F, Scully M, Isbel N, Lommelé Å, Kupelian V, Gasteyger C, Greenbaum LA, Johnson S, Ogawa M, Licht C, Vande Walle J, Frémeaux-Bacchi V; Global aHUS Registry.
Clinical and genetic predictors of atypical hemolytic uremic syndrome phenotype and outcome.
Kidney Int. 2018 Aug;94(2):408-418.
doi:10.1016/j.kint.2018.02.029.
I.F. 8,306
Valenzuela I, Fernández-Alvarez P, Plaja A, Ariceta G, Sabaté-Rotés A, García-Arumí E, Vendrell T, Tizzano E.
Further delineation of the SOX18-related Hypotrichosis, Lymphedema, Telangiectasia syndrome (HTLS).
Eur J Med Genet. 2018 May;61(5):269-272.
Doi:10.1016/j.ejmg.2018.01.001.
I.F. 2.395
Bullich G, Domingo-Gallego A, Vargas I, Ruiz P, Lorente-Grandoso L, Furlano M, Fraga G, Madrid Á, Ariceta G, Borregán M, Piñero-Fernández JA, Rodríguez-Peña L, Ballesta-Martínez MJ, Llano-Rivas I, Meñica MA, Ballarín J, Torrents D, Torra R, Ars E.
A kidney-disease gene panel allows a comprehensive genetic diagnosis of cystic and glomerular inherited kidney diseases.
Kidney Int. 2018 Aug;94(2):363-371.
doi: 10.1016/j.kint.2018.02.027.
I.F. 8,306

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Vascular Biology and Metabolism (VAM)

Overview

Publications

Group Leader: Anna Meseguer Navarro

Research Areas