Neurosciences

Overview

The Neuroscience area is consolidating its position as one of the largest clusters of research labs working on neurological diseases across Europe. Thirteen groups are currently part of this area, working closely with top clinicians at the hospital. The area encompasses different aspects related to neuroscience, such as neural development, neurodegeneration, neuroimmunology, neurological pain, mental health, neurosurgery, pediatric neurology or neuroimaging

There are groups also focused on cell signaling and apoptosis and translational bioinformatics.

Publications

242

total

1850.832

impact factor

7.648

average impact factor

Group Leader: Joan X. Comella Carnicé

team

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Our work is mainly focused in the characterization of the physiological roles of the death receptor antagonist, FAIM-L. We have evidenced its interaction with other proteins, particularly XIAP and Siva-1, confirming that FAIM-L is involved in some neuronal plasticity processes, such as pruning and long term depression, through stabilization of XIAP level and interaction with Siva. These results, added to the previous finding of our group that FAIM-L controls neuroinflammation in Alzheimer’s disease models by modulating TNF effects, allows to position FAIM-L as an interesting target for the treatment of the disease. We have also completed the characterization of the in vivo faim knockout model, which has brought a surprising link with epilepsy. As new and ongoing projects, we are investigating the role of FAIM-L in other pathological situations, such as diabetic retinopathy, in collaboration with other VHIR groups, and developing tools to characterize FAIM-L expression.

Neurosciences

Overview

Publications

Group Leader: Joan X. Comella Carnicé

Research Areas